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You are here: Home / Science & Technology / Good Mojo

Good Mojo

by Tim F|  September 10, 20079:13 am| 9 Comments

This post is in: Science & Technology

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B-J favorite drug resveratrol (RV) keeps cranking out the hits:

We report here that chronic treatment with RV in a subapoptotic concentration induces senescence-like growth arrest in tumor cells. In contrast to the widely accepted antioxidant property of RV, we demonstrate that one causative stimulus for senescence induction by chronic RV is an increased level of reactive oxygen species (ROS). The ROS formed upon RV exposure include hydrogen peroxide and superoxide and originate largely from mitochondria. Consistently, co-incubation with the antioxidant N-acetyl cysteine interfered with RV-mediated reactivation of the senescence program. Molecular mediators on the way from increased ROS levels to the observed growth arrest include p38 MAPK, p53, and p21. Moreover, we provide evidence that RV-initiated replication stress, apparent by activation of the ataxia telangiectasia-mutated kinase pathway, is associated with increased ROS levels and senescence induction. This is the first report linking cell cycle effects with a pro-oxidant and pro-senescent effect of RV in cancer cells.

We knew that resveratrol has weird cancer preventative properties, but here is the first sign that RV treatment can help kill mature cancer cells. Read through our resveratrol archives to get a sense of the almost ludicrously positive effects of this simple compound.

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Reader Interactions

9Comments

  1. 1.

    Zifnab

    September 10, 2007 at 9:29 am

    With all the plugs this stuff gets, it should really start buying banner space to support the site.

    I’d take pictures of juiced-up super mice and purple pills over John McCain’s withered visage any day.

  2. 2.

    The Other Steve

    September 10, 2007 at 9:40 am

    Could someone please translate this to english?

    Thanks!

  3. 3.

    Tim F.

    September 10, 2007 at 9:45 am

    Could someone please translate this to english?

    I did.

    “RV treatment can help kill mature cancer cells.”

  4. 4.

    Pb

    September 10, 2007 at 9:46 am

    In English, from China:

    In the study resveratrol-fed mice showed an 87 percent reduction in their risk of developing prostate tumors that contained the worst kind of cancer-staging diagnosis. The mice that proved to have the highest cancer-protection effect earned it after seven months of consuming resveratrol in a powdered formula mixed with their food.

    Other mice in the study, those fed resveratrol but still developed a less-serious form of prostate cancer, were 48 percent more likely to have their tumor growth halted or slowed when compared to mice who did not consume the compound, according to the study.

  5. 5.

    Wilfred

    September 10, 2007 at 10:06 am

    Tim, is resveratol present in ipé roxo?

  6. 6.

    CaseyL

    September 10, 2007 at 10:07 am

    Y’know, I would order a bottle of supplements immediately, except that the sites you have previously linked to all seem to: 1) slam one another’s formulations (“There can be only One! And it’s ours!”); and 2) recommend RV be taken with exacting dosages of about 5 other enzymes.

  7. 7.

    Punchy

    September 10, 2007 at 10:58 am

    Tim, I’m confused a little. Can you explain this to me:

    RV is an anti-oxidant. It prevents oxidation of other compounds by oxidizing itself (hence, the cysteine oxidation to cystine inhibiting the role of the superoxide). So how is it so successful in the prescence of other pro-oxidants?

    Secondly, do you forsee any deleterious side-effects of the increased formation of superoxide (and/or HOOH)? The former is highly damaging. I would think that, along with senescence, it could/would cause a number of protein-damaging oxidative and/or radical processes.

  8. 8.

    Bob In Pacifica

    September 10, 2007 at 9:21 pm

    Will it help with my erection?

  9. 9.

    ImJohnGalt

    September 11, 2007 at 2:36 pm

    Depends. Is it a bungalow or a split-level?

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