Come for the politics, stay for the snark.

I like you, you’re my kind of trouble.

Optimism opens the door to great things.

Too often we confuse noise with substance. too often we confuse setbacks with defeat.

fuckem (in honor of the late great efgoldman)

T R E 4 5 O N

Balloon Juice has never been a refuge for the linguistically delicate.

Russian mouthpiece, go fuck yourself.

This fight is for everything.

I’m pretty sure there’s only one Jack Smith.

“Everybody’s entitled to be an idiot.”

If you tweet it in all caps, that makes it true!

You cannot shame the shameless.

Come for the politics, stay for the snark.

After roe, women are no longer free.

Jesus, Mary, & Joseph how is that election even close?

No one could have predicted…

if you can’t see it, then you are useless in the fight to stop it.

I did not have this on my fuck 2022 bingo card.

Yeah, with this crowd one never knows.

I’d try pessimism, but it probably wouldn’t work.

Since when do we limit our critiques to things we could do better ourselves?

Technically true, but collectively nonsense

They fucked up the fucking up of the fuckup!

We are builders in a constant struggle with destroyers. let’s win this.

You are here: Home / Science & Technology / Good Mojo

Good Mojo

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B-J favorite drug resveratrol (RV) keeps cranking out the hits:

We report here that chronic treatment with RV in a subapoptotic concentration induces senescence-like growth arrest in tumor cells. In contrast to the widely accepted antioxidant property of RV, we demonstrate that one causative stimulus for senescence induction by chronic RV is an increased level of reactive oxygen species (ROS). The ROS formed upon RV exposure include hydrogen peroxide and superoxide and originate largely from mitochondria. Consistently, co-incubation with the antioxidant N-acetyl cysteine interfered with RV-mediated reactivation of the senescence program. Molecular mediators on the way from increased ROS levels to the observed growth arrest include p38 MAPK, p53, and p21. Moreover, we provide evidence that RV-initiated replication stress, apparent by activation of the ataxia telangiectasia-mutated kinase pathway, is associated with increased ROS levels and senescence induction. This is the first report linking cell cycle effects with a pro-oxidant and pro-senescent effect of RV in cancer cells.

We knew that resveratrol has weird cancer preventative properties, but here is the first sign that RV treatment can help kill mature cancer cells. Read through our resveratrol archives to get a sense of the almost ludicrously positive effects of this simple compound.

Reader Interactions

9Comments

  1. 1.

    Zifnab

    With all the plugs this stuff gets, it should really start buying banner space to support the site.

    I’d take pictures of juiced-up super mice and purple pills over John McCain’s withered visage any day.

  4. 4.

    Pb

    In English, from China:

    In the study resveratrol-fed mice showed an 87 percent reduction in their risk of developing prostate tumors that contained the worst kind of cancer-staging diagnosis. The mice that proved to have the highest cancer-protection effect earned it after seven months of consuming resveratrol in a powdered formula mixed with their food.

    Other mice in the study, those fed resveratrol but still developed a less-serious form of prostate cancer, were 48 percent more likely to have their tumor growth halted or slowed when compared to mice who did not consume the compound, according to the study.

  6. 6.

    CaseyL

    Y’know, I would order a bottle of supplements immediately, except that the sites you have previously linked to all seem to: 1) slam one another’s formulations (“There can be only One! And it’s ours!”); and 2) recommend RV be taken with exacting dosages of about 5 other enzymes.

  7. 7.

    Punchy

    Tim, I’m confused a little. Can you explain this to me:

    RV is an anti-oxidant. It prevents oxidation of other compounds by oxidizing itself (hence, the cysteine oxidation to cystine inhibiting the role of the superoxide). So how is it so successful in the prescence of other pro-oxidants?

    Secondly, do you forsee any deleterious side-effects of the increased formation of superoxide (and/or HOOH)? The former is highly damaging. I would think that, along with senescence, it could/would cause a number of protein-damaging oxidative and/or radical processes.

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