There are few short-term options.
1. Let the virus go & thousands die.
2. Lockdown & release cycles which will destroy economy and society
3. Aggressive test, trace, isolate strategy supported with soft physical distancing. https://t.co/3NYfhOxa6x— Devi Sridhar (@devisridhar) April 14, 2020
Global #coronavirus cases surpass the 2 million mark https://t.co/eUzJ40Jcvb
— delthia ricks ? (@DelthiaRicks) April 15, 2020
Singapore is playing an "A" game of infection control, and they just had to go into lockdown. We're not even close to their capabilities.
It may be time to swing for the fences.
Lesson From Singapore: Why We May Need to Think Bigger https://t.co/H21CMpI3Ym
— Aaron E. Carroll (@aaronecarroll) April 14, 2020
Mike Pence says 24 percent of the counties in the US have no coronavirus cases. Which means that three-fourths do. That’s not necessarily good news. pic.twitter.com/u45FrscBbm
— Jim Roberts (@nycjim) April 15, 2020
Dr. Fauci on minimum requirements to reopen: "You've got to be able to identify, isolate, get out of circulation, and do adequate and appropriate contact tracing as new cases arise." pic.twitter.com/tvwWSpxBIe
— NBC News (@NBCNews) April 15, 2020
NEW: We examined data from several cities to determine how many people were actually dying due to the coronavirus. Our review suggests a significant undercount across the nation. My latest w/ @lisalsong and @jeffykao: https://t.co/Da5AY3nl7r
— Jack Gillum (@jackgillum) April 14, 2020
In recent weeks:
* Boston-area at-home deaths up 20%
* Detroit dead-body calls up 275%
* NYC daily home deaths up 471%Our @ProPublica review points to a big undercount in U.S. deaths related to the coronavirus:https://t.co/Da5AY3nl7r
— Jack Gillum (@jackgillum) April 15, 2020
The theory that all the people dying are from causes other than COVID is nuts. Maybe two airplanes worth of people died in NYC hospitals yesterday of their preexisting conditions that aren't normally fatal suddenly becoming fatal? That's way scarier! How the fuck do we stop that?
— The face toucher (@JonIsAwesomest) April 14, 2020
Calling all you "But the flu" people … https://t.co/Q0DMANIQV9
— Helen Branswell (@HelenBranswell) April 16, 2020
Taiwan, Iceland, Germany and South Korea got their coronavirus responses right. Here's what the rest of the world can learn from them. https://t.co/K7g7vOJewi
— CNN International (@cnni) April 16, 2020
Temporary hospital in Chinese city of Wuhan closes with fewer than 300 patients in Hubei province now being treated for coronavirushttps://t.co/bpCW4AVen5 pic.twitter.com/PiCEN6WczP
— BBC News (World) (@BBCWorld) April 15, 2020
Australia to keep coronavirus restrictions for four more weeks despite success https://t.co/XRLn9FZ30B pic.twitter.com/9xqAjuwlMv
— Reuters (@Reuters) April 16, 2020
Certain countries in Europe — Germany, Denmark, the Czech Republic, Austria and Norway — are beginning to ease their coronavirus restrictions. Here's how they got to this point and what lies ahead for them:https://t.co/8mXeI9NC7Y
— CNN International (@cnni) April 16, 2020
UK must maintain some social distancing until coronavirus vaccine found, scientist advising government sayshttps://t.co/SLGoslHRxs
— BBC News (UK) (@BBCNews) April 16, 2020
Coronavirus: How California kept ahead of the curve https://t.co/v0Qc0Xw0wH
— BBC News (World) (@BBCWorld) April 16, 2020
Rutgers U group has gained @US_FDA approval for a saliva #COVID19 test — no swabs or blood, just spit. Catch is, it requires work in their lab, where they can process 10,000/day. Not point-of-care or scaleable, yet. But promising.https://t.co/N6Zrp60IGy
— Laurie Garrett (@Laurie_Garrett) April 15, 2020
Japanese city of Hokkaido, which initially saw a drop in coronavirus cases, facing second wave of infections https://t.co/xYuz9M01fL
— BBC News (World) (@BBCWorld) April 16, 2020
… After the Daegu outbreak, the South Korean government began a massive testing program to try and track the epidemic. Japan has done the opposite.
Even now, more than three months after Japan recorded its first case, it is still only testing a tiny percentage of the population.
Initially, the government said it was because large-scale testing was a “waste of resources”. It’s now had to change its tune a bit and says it will ramp up testing – but several reasons appear to have slowed it down.
Firstly, Japan’s health ministry fears that hospitals will be overwhelmed by people who test positive – but only have minor symptoms. And on a wider scale, the testing is the responsibility of local health centres and not on a national government level.
Some of these local centres are simply not equipped with the staff or the equipment to deal with testing on a major scale. Local hotlines have been overwhelmed and even getting a referral from a doctor is a struggle.
The combination of these reasons mean authorities in Japan don’t have a clear idea of how the virus is moving through the population, says Professor Shibuya.
“We are in the middle of an explosive phase of the outbreak,” he said.
“The major lesson to take from Hokkaido is that even you are successful in the containment the first time around, it’s difficult to isolate and maintain the containment for a long period. Unless you expand the testing capacity, it’s difficult to identify community transmission and hospital transmission.” …
India coronavirus: All major cities named Covid-19 'red zone' hotspots https://t.co/u2ItAlPQVl
— BBC News (World) (@BBCWorld) April 16, 2020
The Strategic National Stockpile has sent out 19.1 million tablets of hydroxychloroquine to cities around the country, a FEMA spokesperson confirmed. About 10.1 million are going to the Departments of Defense and Veterans Affairs. https://t.co/sDB9I03LN4
— Natasha Bertrand (@NatashaBertrand) April 15, 2020
Hydroxychloroquine, the malaria drug that Donald Trump has praised, didn’t help patients clear the coronavirus and was much more likely to cause side effects https://t.co/i6lTskiOy6
— Bloomberg Technology (@technology) April 15, 2020
.@nancyayoussef and @glubold have a really good story out now about how COVID-19 on Theodore Roosevelt probably came via the COD.https://t.co/sB5lEVqE6U
— Sam LaGrone (@samlagrone) April 15, 2020
OzarkHillbilly
Profit over people, cost over care: America’s broken healthcare exposed by virus
It’s a feature, not a bug.
Laying off doctors and nurses during a pandemic, yeah, that makes sense!
Choice! It’s all about the right of my employer to choose my healthcare profiteer… I mean “provider”.
HA! The idea of the trump admin reflecting on something other than the image they see in the mirror.
Or in those infamous last words:
Greatest. Healthcare. In. The. World.
?BillinGlendaleCA
@OzarkHillbilly:
It does make sense since doctors and nurses specialize. For example an OR nurse and an ICU nurse are not substitutes, they have specialized skills.
SFAW
WTF does “It may be time to swing for the fences” even mean? That the US should go into total lockdown?
English is a great language for expressing both obvious and subtle concepts. It’s too bad more allegedly-native-speakers don’t know how. [Yes, I realize it’s a tweet. So?]
SFAW
@?BillinGlendaleCA:
They’re getting moved from non-direct care positions to direct care positions at various hospitals, including my wife’s. Some have refused, others not. [My wife is back to wearing scrubs, after being away from that type of work for five-plus years.] NPR interviewed one or more nurses in other areas of the country, who are being asked to do the same thing. In some cases, it may make sense. In others, it sounds like asking a hip/knee surgeon to do rocket/brain surgery.
SFAW
@OzarkHillbilly:
Thank FSM the tyrant Obama wasn’t allowed to move people off employer-“supplied” medical insurance. Same goes for would-be tyrant Elizabeth Warren. [In years past, I might have written “those commies,” but since 2016, that’s apparently a NBD, according to some.]
?BillinGlendaleCA
@SFAW: The kid’s hospital asked for volunteers in the OR for partial furloughs, she volunteered since she’s in a better financial place* than some of her colleagues. So rather than work 3/12, she’s working 2/12 and losing a 1/3 of her pay.
*She’s single and doesn’t have any children.
Amir Khalid
Director-General of Health Dr Noor Hisham Abdullah is giving his daily media briefing right now.
Meanwhile, Malaysia’s worldometer numbers for today: 110 new cases, total 5,182; one death, total 84. New diagnoses continue their downward trend. 2,766 patients, 53.4% of the total, have recovered and been discharged. Dr Noor Hisham attributes the low mortality and good recovery rate to a policy of isolating and treating patients in hospital as early as possible in the cycle of the disease. He also praises the cooperation from private-sector healthcare: many doctors and nurses are now volunteering in public hospitals.
WereBear
It’s going to be a mess, nationally, because the ones in charge are all a mess. And we won’t get out of it until next January — hopefully. I’m resigned to that, thanking my lucky stars I’m in a blue state, and figuring on eventually losing my job as the rosy false optimism clears from the nation’s windshield.
All the Republican tendencies towards doing the exact wrong thing, at the exact wrong time, over and over, have come to full flower.
Much like that plant which flowers once a century and smells like rotting meat.
OzarkHillbilly
@?BillinGlendaleCA: They share skills too. That way an ICU doctor who has been on duty for 13 and a half hours can get a break from doing some of the more mundane things and concentrating on only those things that require his specialized skills.
SFAW
@?BillinGlendaleCA:
I hope her sacrifice is appreciated, by both her colleagues and her employer. [I say that absolutely sincerely.] Unfortunately, my experience has been that hospitals tend to be more of “yeah, but what have you done for us lately?” kinds of places.
On the other hand, not being able to perform elective surgery means a lot of hospitals will — even if they don’t go under — suffer huge financial losses.
But thank FSM the cruise lines are getting bailed out. [No wordplay intended.]
?BillinGlendaleCA
@WereBear:
The corpse flower blooms a bit more often, but does smell like rotting meat. They raise them at The Huntington.
SFAW
@WereBear:
Quit yer bleedin’ whining. Things are more-or-less OK for the one percenters, which is all that matters to Rethugs.
?BillinGlendaleCA
@SFAW: I doubt that her hospital will have much in the way of financial difficulties, if a celebrity is in the hospital it’s either her’s or UCLA.
SFAW
@?BillinGlendaleCA:
Sorry, but all I could think of was “And when they’re fully-grown, they become Republicans.” But without the “looking nice” part of the equation.
WereBear
@SFAW: A whole new take on “Feed me, Seymour!”
?BillinGlendaleCA
@SFAW: Corpse flower @ The Huntington.
?BillinGlendaleCA
@OzarkHillbilly: It depends, in many cases they don’t share enough skills to be useful.
Amir Khalid
@?BillinGlendaleCA:
I simply don’t understand furloughing medical personnel at a time like this, when you need all of them that you can get.
rikyrah
@?BillinGlendaleCA:
Beautiful, in an odd way?
OzarkHillbilly
@SFAW: And speaking of which: Millionaires to reap 80% of benefit from tax change in US coronavirus stimulus
Because this economic downturn has hit them soooooo hard. Do you know how much it costs to rent a house in the Hamptons so you can shelter away from the hoi poloi????
And let’s not forget,
Amir Khalid
@?BillinGlendaleCA:
They’re found in the wild in southeast Asia.
SFAW
@?BillinGlendaleCA:
Glad for her. My wife’s hospital, which has been financially tight (as in, they don’t have a lot of cash to spend on needed stuff) for awhile, may not be so fortunate. And it’s not as if she could/would transfer to Mass General (a/k/a MGH) anytime soon.
So, let’s see, the Murderer-in-Chief’s dumbass destructive dithering will probably lead to: shitloads of deaths from “it’s just the flu, libtards,” the near-destruction of the US economy, the near-destruction of significant parts of the healthcare system, the impoverishment of millions of Americans. All to pwn the libtards, or at least pwning those persons unwilling to state that he is the greatest person ever to walk the Earth.
OzarkHillbilly
NYT:
OzarkHillbilly
@SFAW: Well, he did have a lot of help from rank and file Republicans. It’s not like he did it all by himself.
Credit where credit is due.
Amir Khalid
@OzarkHillbilly:
Only 82%? The GOP is slipping.
SFAW
@OzarkHillbilly:
Good Christ.
How close are we to Oктября?
rikyrah
@OzarkHillbilly:
Maddow has been sounding the alarm about the non-reporting of what’s going on in senior care facilities. How the government isn’t tracking it AT ALL??
SFAW
@OzarkHillbilly:
True enough, but you gotta start somewhere. Before COVID-1 (thanks KellyAnne!), I would have put Traitor Turtle at the head of the tumbrel procession, but with the Murderer-in-Chief’s performance for the last two-plus months, I think I’ve moved Moscow Mitch back to “number 2.” Which I guess is also appropriate.
Eolirin
@SFAW: It’s an 82 billion dollar tax cut someone snuck into a 2 trillion dollar spending package. And it’ll be pretty easy to reverse, especially when we’re going to need to do significant tax reforms when we get back into power anyway. Wouldn’t have been worth fighting to remove.
Anne Laurie
@?BillinGlendaleCA: A massive orange corolla with a gross green ‘tongue’ emerging from it… maybe we can declare the corpse flower official emblem of the Trump presidency.
He’d probably love the ‘Lord of the Flies’ nickname!
SFAW
@Eolirin:
My “Good Christ” and October Revolution comment was aimed at the “peasants have to fight for testing, while the rich get pampered, etc.” concept. Although the parallel might have been better suited to July 14th, rather than October. [Disclaimer: not enough of an historian to know if either one makes sense. But, hey, if I can’t make bullshit analogies at Balloon Juice, where can I?]
Eolirin
@SFAW: Ah, right. Yeah, understood.
OzarkHillbilly
@SFAW: You know, my wife speaks 4 different languages and I have a hard enough time separating out the English words and trying to make sense of them. Now I gotta do the same with you?
SFAW
@Anne Laurie:
“Dr Fauci came to me, with tears in his eyes, and said ‘Sir, with the way you’ve shown outstanding leadership — the BEST leadership! — on the whole sharonavirus thing, some of the CDC think they should maybe start calling you ‘Beelzebub.’ It’s an old term, in some not-American language, it means ‘Lord’ or something, I think it’s appropriate, don’t you?’ I’m glad to see Dr. Fauci finally giving me the respect I’m due.”
Robert Sneddon
@OzarkHillbilly: Throat swab tests are to confirm ongoing COVID-19 infections by detecting actual virus particles in people’s mucus and saliva. They’re complicated to do, requiring lab techs operating PCR machines with consumable reagents and analysis of results which means each one takes significant time to carry out.
The blood tests for antibodies are a lot simpler, on the level of pregnancy home-test kits but no-one who is pushing them at the general public is talking about error rates. The one actual statement about this I’ve heard was from a British government minister a couple of weeks ago who, during a briefing mentioned that one unnamed series of prototype tests they were considering buying was returning false results three times out of four. Other similar tests are known to react to many different coronavirus antibodies, not just COVID-19 so if someone had a cold in the past few years they’d get a positive result for antibodies regardless.
Testing, like masks and contact tracing, are not a golden bullet that will stop this disease in its tracks. Stay at home, wash your hands.
SFAW
@OzarkHillbilly:
Well, I’m honored that you even consider trying to make sense out of my “musings.” The Cyrillic (well, “Kyrillic,” I guess) is (at least according to Google) “October” in Russkie. [I had always thought it was “октябрь,” but the translator tells me otherwise.] It was a reference to the October Revolution of 1917.
Of course, you probably already figured that out, and are just fuckin’ with me. Which is OK.
Which four languages does Mrs. Ozark speak? I only speak (what
usuallysometimes passes for) English, and Ig-pay Atin-lay.WereBear
@Anne Laurie: More appropriate than I knew!
Barbara
@OzarkHillbilly: This kind of random, disorganized half assed testing isn’t helping much.
OzarkHillbilly
@SFAW: Catalan (her native language), Spanish (her dictator enforced official language), French (which she loves to use to correct my hillbilly pronunciations of place names around here) (to which I always say, “You go ahead and ask how to get to the Courtois Creek and see how far you get) (in hillbilly it’s “Coat-away) and English. When she gets tired she mixes them up and uses different grammars too.
Amir Khalid
@OzarkHillbilly:
So, does Mrs Ozark call the city in Michigan Detroit or “duh-trwah”?
cwmoss
@?BillinGlendaleCA: At UW in Seattle, too.
SFAW
@OzarkHillbilly:
Neat. Being half-Canuck, I sometimes (mentally) correct when people here pronounce an obviously-French name using ‘Murican pronunciation. [Minor examples: “Gagnon” is “GAG-non” for most around here, but “Gahn-yon” to me. And “Gervais” is pronounced as “Jarvis” by a lot. Oy.]
I do not generally switch between English and Pig Latin mid-sentence, however.
SFAW
@Amir Khalid:
This comment is merely the latest one of yours which earns my admiration.
Sab
@SFAW: In NE Ohio we pronounce Ghent the same as gent, with a j sound.
marklar
@OzarkHillbilly:
It does go both ways. Growing up in Moan-Ree-all, Kay-Beck, (Anglicized to Muntreal, Kweebec) the Francophones would usually clip H’s from English words starting with them, and hadding them to words lacking them. Thus, the ‘ardware store called “Handy Andy” was pronounced “_andy h’Andy”.
zhena gogolia
@SFAW:
Your problem is that “until October” would have the month’s name as октября, because it would be in the genitive case. But the nominative case (i.e., the form in which the word would be given in the dictionary and the form it would be as the subject of a sentence) is октябрь.
artem1s
24 percent of US counties have had little or no testing
FTFY Mikey.
Barbara
@artem1s: 24% of counties representing 2% of the population or less. Fucking idiot.
Enhanced Voting Techniques
@Barbara: who are all one asymmetrical trucker away from their own outrbreak.
Enhanced Voting Techniques
Not thousands, millions, if the REAL Americans get their their wet dream the virus will infect 100% of the population in 20 days and kill 1%, that’s 3 million deaths in the United States over two months. Not to mention the extra deaths from other people who can’t get medical help, then the people who will be crippled from the illness and then vast numbers who will be sick for a month and unable to work for month from it. That what, 22% of the population, at lest. So the economy is screwed ether way, but dead or crippled is permanent.
Amir Khalid
@marklar:
Also, they would not pronounce the plural s in Enlish words because the plural s is usually silent in French.
YY_Sima Qian
Early indications of (so far) small second waves, triggered by imported cases, are showing in three regions in China: Harbin in northeastern China, Beijing, and Guangzhou.
There is a growing cluster in Harbin, the capital of Heilongjiang Province. “Patient 0” appears to be a young student returning from the US, apparently asymptomatic that produced negative PCR and antibody results during screen at point of entry, as well as the start and finish of 14 day self-quarantine. Days later, she was identified as a close contact of a family cluster living downstairs in the same apartment building, and she tested positive for antibodies. Perhaps she was one of those asymptomatic cases that was still contagious, but produced low levels antibodies upon self-healing. It is not published how she infected the daughter of the family living downstairs, but most likely she breached self-quarantine at one time or another. The daughter then infected all of her family living in the same apartment. The father of the family then had a banquet with some friends, and infected several people at the event. One elderly gentle, who turned out to be a super-spreader, then went to a hospital for cerebral apoplexy, and then transferred to another hospital after developing a fever, and went on to infect his own family members, a number of his fellow patients, their caretakers, their families, and few of the nurses working in the two wards, before finally being transferred to isolation ward. 23 confirmed cases found over 7 days from this transmission chain, as well as a number of asymptomatic cases, though some of the confirmed cases are people who were classified as asymptomatic, who then developed symptoms. Of the 11 asymptomatic cases from Harbin yesterday, 6 are nurses working in hospitals. Worryingly, two of the nurses did not work in the hospitals that the super spreader was treated in, and the sources of their infections are currently unknown. Several hundred close contacts of these cases have been traced and quarantined. The situation is still developing.
Clearly there are gaps in Harbin’s containment and prevention measures in hospitals. It seems hospitals in Harbin are not screening patients checking in for in-patient care, even in the respiratory disease ward. Nurses in non-COVID wards appears to be inadequately equipped, trained or alerted against potentially infected patients. I have no idea how nurses in the respiratory disease ward could have been infected, one would think they would be properly equipped, trained and alert. There is now an investigation into the hospitals. At least Harbin is being very transparent with case reports, including the asymptomatic cases. It seems all hospitals in China will have to adopt the procedures and protocols as those in Wuhan.
For moral of the story for the common folks is: social distancing should be maintained even after lock downs end, it is not an occasion to party and bar hop with friends and restart social life! It does not matter how low the official case count is. Hospitals should operate under the assumption that any incoming patient may be a SARS-CoV-2 carrier, and protect the HCWs accordingly.
The new cases in Beijing is scary in a different way. A returnee from the US was tested twice upon entry, both negative. He was deemed a close contact of another confirmed case on the flight, and was transferred from general centralized quarantine for returnees to special quarantine for close contacts. He tested negative again at the end of the 14 day period, and was released to go home. He then developed symptoms a few days later, and proceeded tested positive. By then he had infected three of his family members, with another one currently classified as suspect. Dozens of close contacts of these cases have been traced and are under quarantine. By now it is clear that a percentage (albeit very small) of cases can have incubation periods longer than 14 days. They can slip through the current standard containment measures employed around the world, and cause new outbreaks.
5 more confirmed and 11 more asymptomatic domestic cases were found in and around Guangzhou yesterday. Most are African nationals living in Guangzhou (though one American), all are close contacts of confirmed cases or had frequented known hot spots, so their epidemiological histories are well understood. They were found via contact tracing or community screening. Fortunately, all of these asymptomatic cases have already been placed under medical quarantine (either as close contacts, or because Guangzhou is placing all members of the African community under medical quarantine, pending test results), so the transmission chains have been cut. Most of the confirmed cases were reclassified from asymptomatic. Perhaps the draconian methods Guangzhou government has employed on its African community will actually contain this outbreak.
I have been troubled for several days by some of the data from Wuhan and Hubei. It is clear from case reports from the rest of China that the majority of asymptomatic cases (imported or domestic) do eventually develop symptoms and become confirmed. However, we know several hundred asymptomatic cases have been found in Hubei over the past month (including 37 just yesterday). Yet, only 3 new confirmed cases over the same span, and I do not believe they were reclassified from asymptomatic. So why do the asymptomatic cases in Hubei not develop symptoms?! I hope it is not because the municipal and provincial governments are keeping these cases “asymptomatic”, so they can keep the new confirmed case count to 0! On the other hand, the Chinese government has mandated that all COVID-19 treatments are free (even the weeks on the ECMO that costs tens of thousands of US dollars a day), but only if the patient is a confirmed case. I would expect at least some of the patients’ families to raise a stink if the hospitals refuse to confirm them, despite developing clear symptoms. Even if the local and regional authorities are stretching the definition of “asymptomatic”, it is not likely to be a gap in epidemic containment efforts, though. Asymptomatic cases are treat the same as confirmed cases in terms of quarantine and contact tracing. They just receive no medical treatment.
While researching the above issue, I found a recent report from Wuhan municipal health commission: in the week after the lock down of was lifted Apr. 8, 225,999 people have been screened (number of individuals, not number of tests), 130 asymptomatic cases have been found, and no confirmed cases. That is a 0.0575% positive rate. Over the past several weeks, authorities have only found a handful of confirmed and asymptomatic cases to have been exported from Hubei to other parts of China, despite millions of people traveling. It seems the epidemic has truly been suppressed in Wuhan and Hubei.
jonas
@Barbara: Yep, the same depopulated counties that when you color them red on a map, prove Trump won the popular vote.
*headdesk
jonas
@OzarkHillbilly: Reminds me of the time I was in the Lexington, KY area and there’s a town near there called Versailles, which my host explained to this fancypants coastal elite was pronounced “Ver-sayles”.
snoey
@marklar: The French, assuming that we are barbarians, pronounce Greg LeMond’s name as the fruit with a “d” at the end.
SFAW
@zhena gogolia:
Thanks for zhena-splaining. I’ll probably continue to make the same (or similar) mistake, but maybe I’ll remember what you’ve tried to teach me.
Barbara
@jonas: “North Versailles” is a town just outside Pittsburgh. Pronounced “ver-sails.” However, even more bizarre, there is a town in Virginia called “Buchanan” that is pronounced as if it were spelled “Buck Hannen.” And the people who settled that patch of woods were definitely from the place where the name was pretty common so I have no idea what happened there.
Barbara
@Enhanced Voting Techniques: “Truck stop transmission” was definitely a thing with HIV.
zzyzx
There’s a lot of controversy on how to pronounce the final word in the Des Moines in King County Washington. Some have the z sound at the end, others don’t.
Hoodie
@OzarkHillbilly: It’s hard enough to find Courtois Creek without getting the name wrong. Don’t get me started on the Huzzaus.
Another Scott
@YY_Sima Qian: Thanks for these reports. They are troubling to me though.
What is your feeling about the false negative rate (and overall sensitivity) in tests in China? Is it low enough to account for these findings. Over here we hear stories that tests have 30% false negative rates. :-( It sounds like the rate is much lower there, but is it low enough? Are the tests sensitive enough to detect low levels of virus? Or are there really cases where it takes longer than 2 weeks for detectable virus loads and symptoms to develop?
I firmly believe that test and trace is the sensible way forward, but if the tests cannot be trusted, then we’re continuing to fly blind (but with the added false sense of security that the tests are meaningful)… :-(
Thanks again.
Cheers,
Scott.
Another Scott
@zzyzx: My mom reminded me:
“There is no noise in Illinois.”
The American English language is weird.
Cheers,
Scott.
Barbara
@Another Scott: But does she refer to Cincinatti as “cincinatta”? Or “Louisville” as “Lew-a-ville”?
ETA: I love this kind of diversion but WaPo tells me that today is going to be a horrendous day for death from CV-19.
Geminid
@Barbara: And further down the Valley Staunton is pronounced “Stanton,” like Lincoln’s Secretary of war, not “Staunton,” like the English chess master. It could be a Scotch Irish thing.
Ruckus
@Amir Khalid:
In our system we specialize, both in skills and labor costs. So that nurse that works in a high cost OR gets paid a different rate than the floor nurse on a ward. Put that nurse on the ward and the ward cost either escalates or the hospital is losing money. It reverberates through the entire system.
IOW the system is based upon cost per disease/operation, not on over all healthcare. This disease throws all of that made up cost containment/cost exorbitant care concept out the window.
Barbara
@Geminid: Well, it is reminiscent of certain mostly upper class pronunciation “conventions” in England, whereby “St. John” is pronounced “sinjin” (famous scene from Four Weddings and a Funeral) and “Magdalene” is pronounced “maudlin” (giving rise to the word). An English waiter in Oxford sheepishly asked us how we would pronounce the word spelled “magdalene” and we told him, “magda-lin” and he said he would too, but “around here” it’s ‘maudlin.'” Derby is “darby” and so on. We found car rental people to be very helpful with these sorts of things
YY_Sima Qian
@Another Scott: I think the false negative rate for PCR tests was as high as 30 – 40% back in late Jan. to early Feb. in China. It then improved to 15 – 20% in Feb., and approximately 5 – 10% now. That is why China (and others in East Asia) is doing multiple PCRs for both confirmation and clearance even now, supplemented by serology for antigen/antibody and chest CTs. I had to clear two PCRs, two blood screens and one chest CT to be transferred from buffer ward to standard ward. Anyone entering the country is screened at least twice during 14 day mandatory quarantine. A COVID-19 patient is only discharged after two to three negative PCRs spaced at least 24 hours apart, cessation of outward symptoms, and significant improvement in the lungs on chest CT. Anyone traveling from Wuhan to the rest of China first need a negative PCR at Wuhan, and is then tested again at the destination.
However, the false negative rates are estimates for samples with enough viral particles that the PCR assays should produce positive results. It does not account for the fact that early on during th course of infection there may not be enough viral particles in the nasal or throat area to be detected, or that late in the course of infection most of the virus may be in the lungs and other internal organs, or that some outlier cases would continue to test negative despite having every symptom. PCRs typically can only detect virus from 1 – 3 days before onset of symptoms. That is why PCR tests are not enough by itself, it needs to be employed in conjunction with other tests. That is why thorough contact tracing and isolation of close contacts and suspected cases are critical to get ahead of the curve. With testing alone you will always be several days behind the curve. That is why China is mandating 14 day centralized quarantine for all who enter the country, and 14 day centralized quarantine for recovered patients already discharged from hospital, and 14 day quarantine for close contacts. That is to guard against the false negatives, the asymptomatic and the pre-symptomatics. Some experts in China is recommending 24 day quarantine to be standard.
The fast antibody tests (finger pricks) are even worse in accuracy, and typically can only produce positive results well into the course of infection, often after onset of symptoms. Blood samples directly from the vein is better. I do not know about Abbott’s fast PCR test… Testing alone is not the solution for this disease.
As for Wuhan, even tests that has 30% (or 70%, for that matter) false negative rate should be able to detect the presence of an ongoing outbreak, of even 0.5% of the population is currently infected. Therefore, I do believe the epidemic has been suppressed here.
Mind you, even a 0.0575% positive rate still suggests that there are ~ 10K active asymptomatic cases in metro Wuhan, assuming 18 million people. That also implies 10s of thousands of people may have been infected asymptomatically, and have since recovered, over the course of the epidemic here. Compared to the cumulative 50K confirmed cases in the city, that means an ~ 50% asymptomatic (or very mild) rate, in line with findings from community surveys in Italy and Iceland! Food for thought.
Another Scott
@Barbara: I always chuckle / want to pull my hair out whenever I hear the BBC announcer pronounce “Bernie Sanders”. It’s almost always “Bernie Saunders” with the “u” varying slightly between the people saying it.
Maybe it’s related to the color/colour thing – dunno.
“Hey, let’s add a “u” in there!!”
Cheers,
Scott.
planetjanet
One thing I have done to relieve some of my anxiety is to chart the growth rate of new cases in Virginia. Keep hoping to see that corner turned. The state is good at providing a number of good charts. Looking at the number of cases, it was easier to see how big the increase was when the numbers were small, but not as easy now that it is in the thousands. Their chart does not show a clear decline yet. I took the total number of cases identified and calculated the percent increase. To smooth it out, I also did a five day running average. On March 25, the rate was increasing at 29% a day. On March 30, the Governor issued the stay at home order. As of today, the rate is 6%. We still seem to be stuck at only doing 2000 tests a day. Stay safe.
YY_Sima Qian
It appears that I am not the only one finding Wuhan’s asymptomatic cases to be curious. Just saw an article by a local expert, who explained the difference between the asymptomatic in Wuhan and those elsewhere. After 70+ days of lock down, anyone who could develop symptoms has already done so, has already been isolated and treated, and close contacts (and their contacts) traced and isolated, too. The remaining asymptomatic cases here are truly asymptomatic, and the vast majority of them are not very infectious (no coughing up a storm of viral droplets, no wipe it all over their hands and the surfaces they touch). The asymptomatic cases in Wuhan are not found from contact tracing of transmission chains, but from random community surveys, or the myriad of screens for other purposes (travel, non-COVID intake at hospitals, etc.). The imported or recently infected cases elsewhere in China, who are currently classified as “asymptomatic” due to lack of symptoms, are mostly pre-symptomatic. They will develop symptoms in the coming days, and become confirmed cases. It actually kind of makes sense…
Van Buren
@Barbara: Now tell us how to say “Fauquier”
Another Scott
@YY_Sima Qian: This comment seems to me to be very important and not fully recognized by the US reporting and should have greater visibility. There’s lots and lots of commentary about lack of testing, but very little [about contact tracing] (except for the Google/Apple voluntary contact tracing initiative using Bluetooth) and the occasional mention of the need for someone to hire hundreds of thousands of people to do tracing. If (as it appears) testing alone will never be good enough, then we need to get started on tracing NOW NOW NOW.
Maybe WaterGirl can collect these comments from you and put them in a dedicated page? Or you could be persuaded to do a guest post/Q&A?
Thanks again.
Cheers,
Scott.
Barbara
@Van Buren: Faw-keer, with slight emphasis on the last syllable.
planetjanet
@Barbara: My family includes Buchanans and that use the same pronunciation, “Buck Hannon’. Yes, we are from SW Virginia.
Barbara
@planetjanet: It occurred to me that this might be the way they pronounced it in Scotland (or Ireland, when they became “Scotch-Irish”) but it doesn’t seem to be the way that James Buchanan (among others) pronounced it.
YY_Sima Qian
@Another Scott: Just to be clear, I am not a doctor, virologist, epidemiologist, or public health expert, so take everything I say with a grain of salt! ;-) I think Q&A should be reserved for someone with real expertise, not a random guy on the internet. :-D
A couple of days ago I described China’s “Four Earlies” strategy since late Jan.: early detection, early reporting, early isolation and early treatment. Variations of this strategy is employed by all East Asian countries and regions that are keeping the pandemic under control, and I think should be the fundamental strategy everywhere before vaccines are widely available.
Right now, there is far too much community transmission in too many epicenters in the US for contact tracing to be that useful. Strictly enforced lock downs are needed to suppress the outbreaks enough that the number of new cases and close contacts are not overwhelming even for hundreds of thousands of contact tracers. This army needs to be mobilized and trained starting from now, though, in preparation of that eventuality.
Ksmiami
@SFAW: The line gets pretty long after that. I don’t see a way forward for this country unless we smash the GOP and destroy the right wing media circus
planetjanet
@Barbara: And we are Scotch-Irish, by way of County Tyrone. Makes sense.
Amir Khalid
@Van Buren:
I remember seeing a Cheech and Chong movie where the bad guy was called “The evil Foucaire”.
Amir Khalid
@Barbara:
My guess would have been “fuck ya”, but maybe that’s just me.
Laura Too
@YY_Sima Qian: I am lucky to live in a state that has taken all of your playbook and put it to work. (I read your whole post on that and was thrilled a few hours later to hear our Governor repeat it almost verbatim-just didn’t get to reply before the thread was dead) We can’t get enough tests yet so he won’t open us back up yet and the crazies are getting restless. They are going to stage a protest at the Govenor’s residence Friday. I’m guessing maybe 100 show up. The rest of us will sit at home, point and laugh-or scream. I’ve heard screaming can be theraputic. As for being some rando on the internet, maybe? But you are our beloved rando and you are very good at synthesising volumes of material! Thank you!
Kent
Texans do the same thing. I spent a decade living in Texas and never did get used to all the horrible pronunciations of Spanish place names.
In Waco we had the Brazos River (BRAZ-is)
In Austin the Guadalupe River (Gwad-ah-LOOP)
And so forth.
Jay
@YY_Sima Qian:
last night, coming home, I observed a very young couple at the bus loop. They were definately not “social distancing”. After making out and talking for two bus shifts, ( buses run on the 1/2 hour), they each put on their masks and boarded different buses to go home to their families.
Romeo and Juliet in a Time of Covid isn’t going to end well.
Jay
@YY_Sima Qian:
thank you for your always “must read, must think” posts.
you are providing a very clear window into an aspect that the MSM either ignores in favour of clickbait or murks up.
rikyrah
@YY_Sima Qian:
Should quarantine be extended from 14-21 or 28 days. Would that have helped?
joel hanes
@planetjanet:
In my hometown, there was a family name spelled Cahalan, that almost everyone, including many members of that family, pronounced “Caa – laa – han”
ETA : there were also families named Tymcsm (“Tim-chism”) and Trcka (“Thurchka”) . (The PE teachers in particular had trouble with calling the roll at the beginning of every year.) The Tymcsm boy married Gwendolyn Hofnagle, pronounced “Hoof -naygul”, and they hyphenated, so her married name was Gwendolyn Hofnagle-Tymcsm
Jay
Barbara
@rikyrah:
Going out on a limb, there are probably a few things going on. There probably is a long tail for infectious status that can produce outlier events, but with a disease for which no one has any immunity, these events can result in significant transmission, so we really notice those outliers. Even a relatively uncommon flu type typically encounters many people with some level of resistance if not complete immunity. The second thing is that people are probably understating their level of contact with others. They are not doing anything intentionally wrong, but it’s like counting calories. People really do overlook what they eat during the course of a day if you ask them to report retrospectively. The third thing is that you don’t know for certain when they came in contact with the virus because you don’t know how many other asymptomatic people they encountered.
But the underlying issue is the utter lack of prior exposure, which is going to make the sudden introduction of any disease have a much much worse impact on a population.
I used to wonder why small pox had not decimated Europe the way it had Western indigenous populations, and the answer was that it had probably killed just as many people, if not actually many more, but over the course of hundreds of years, with some percentage of the population having derived resistance, if not from having the disease then from having diseases close in kind (cow pox).
Enhanced Voting Techniques
@Barbara: It did, but that happen during the Neolithic
https://en.wikipedia.org/wiki/Neolithic_decline
Enhanced Voting Techniques
@YY_Sima Qian: The Four Es sounds like what the doctors want here, so I wouldn’t be to surprised if the current round of screaming from the Right is because of the cost and the government being the solution.
Worth noting that Germany, Iceland and Norway are doing similar things. It’s also noticeable that countries that were on the front line for the Cold War like Germany and South Korea are doing the best with this.
StringOnAStick
I’m mailing my 2 week notice to my boss today, no way in Hell am I practicing dental hygiene again until there is a proven effective vaccine. I used to love working with him but he was so cavalier about this disease and is still convinced he already had it. Research says that was influenza A going around in December and early January, but some random FL doctor buddy convinced him “everybody already has had Covid-19 so keep your office open, this is all an over reaction”. Yeah, I’m done.
Kelly
@StringOnAStick: How did your Bend trip go? Between the really late snow this year and the stay home order I may have set a record for fewest ski trips since I started in the early 1970’s.
Barbara
@Enhanced Voting Techniques: Thanks. I think I had read something like this previously. Even during the Bubonic Plague, which is theorized to have killed up to 1/3 of certain populations (though I have read that it is exaggerated to say that 1/3 of all European peoples died), the incidence was thought to have been worse because of various environmental conditions, e.g., failed harvests. But one thing is sure, people living in close contact without prior exposure to a pathogen are at much higher risk of succumbing. I suspect that even now, this is going to be one of the differences between New York City and Italy, and other places.
Suzanne
@Amir Khalid: FWIW, I have been diverted from my normal project work to COVID surge plans in two states…. and it’s looking like they will never be used. Some of these surge spaces have opened and are now closing without seeing a single patient, and the city’s peak (at least the first one) seems to have passed.
But at least one of my clients is carrying on with surge plans that they don’t expect to build, so that they can be more prepared for a mass shooting, terrorist event, or any other surge situation.
I am plenty scared here about societal collapse, and I am (and have been) very scared about what happens if people just decide not to comply with quarantines because they’re going to be homeless or starving…
YY_Sima Qian
@Barbara: You are absolutely correct on the dynamics. People with > 14 day incubation, or significant asymptomatic viral shedding, are low percentage outliers. However, they can cause large outbreaks due to lack of immunity. With all the containment and suppression measures, outbreaks are more likely to be caused by these outliers, not the case during the height of the epidemic. With every cluster I have read about, in China or SK, people close to “Patient 0” initially refused to cooperate with the contact tracers, leading to delayed response.